| A continuum model to analyse spatial cell fluxes from positional labelling data applied to cell migration in oral mucosa. | |
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MedLine Citation:
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PMID: 12139707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel method is presented which allows the estimation of the velocity of migrating cells from positional 3HTdR labelling data in spatially organized epithelial tissues. In a continuum approach, wave-like profiles of labelling index (LI) data, which travel away from the basal layer, are followed and compared with experimental LI profiles. The method yields estimates of migration velocity, cell flow, and turnover time. Results for the ventral tongue mucosa in a group of 55 BDF1 mice that were labelled at the same time of the day and culled at different time points within a 24-h period have been analysed. The results show a strong circadian rhythm in the migration velocity and the related parameters. |
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Authors:
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D Barthel; F A Meineke; C S Potten; M Loeffler |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cell proliferation Volume: 35 Suppl 1 ISSN: 0960-7722 ISO Abbreviation: Cell Prolif. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-07-25 Completed Date: 2002-09-13 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9105195 Medline TA: Cell Prolif Country: England |
Other Details:
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Languages: eng Pagination: 48-59 Citation Subset: IM |
Affiliation:
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University of Leipzig, Institute of Medical Informatics, Statistics & Epidemiology, Liebigstrasse 27, Leipzig D-04103, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Count Cell Movement / physiology* Circadian Rhythm / physiology* Cytological Techniques Epithelial Cells / cytology Mice Models, Biological* Mouth Mucosa / cytology* Thymidine / pharmacokinetics Tongue / cytology Tritium / diagnostic use |
| Chemical | |
Reg. No./Substance:
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10028-17-8/Tritium; 50-89-5/Thymidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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