| The continuous reaction times method for diagnosing, grading, and monitoring minimal/covert hepatic encephalopathy. | |
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MedLine Citation:
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PMID: 23299303 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Existing tests for minimal/covert hepatic encephalopathy (m/cHE) are time- and expertise consuming and primarily useable for research purposes. An easy-to-use, fast and reliable diagnostic and grading tool is needed. We here report on the background, experience, and ongoing research regarding the continuous reaction times (CRT) method. The method has been in clinical use for decades in Denmark for the stated purpose. The method is a 10-minutes, computerised registration of a series of motor reaction times to an auditory stimulus, with results reported as the CRTindex (50 percentile/(90-10) percentile) as a parameter of reaction time variability. The index is a measure of alertness stability and is used to assess attention and cognition deficits. The CRTindex identifies half of patients in a Danish cohort with chronic liver disease, as having m/cHE, a normal value safely precludes HE, it has a broad outcome span reflecting the degree of brain impairment, it shows no learning effect, and it is independent on age and gender. The CRTindex is, therefore, a candidate tool for routine screening, detecting, grading, and monitoring m/cHE. Still, however, further methodological and clinical validation trials are required and are currently being conducted. |
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Authors:
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M M Lauridsen; M Thiele; N Kimer; H Vilstrup |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-10 |
Journal Detail:
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Title: Metabolic brain disease Volume: - ISSN: 1573-7365 ISO Abbreviation: Metab Brain Dis Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610370 Medline TA: Metab Brain Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Gastroenterology and Hepatology, Hospital of South West Jutland, Finsensgade 35, 6700, Esbjerg, Denmark, mettelauridsen@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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