Document Detail

The continuing increase in adenocarcinoma of the uterine cervix: a birth cohort phenomenon.
MedLine Citation:
PMID:  9119549     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Adenocarcinoma of the uterine cervix has been reported to be increasing among young white women and earlier studies suggest a birth cohort pattern for the observed increase. No study, however, has examined the time trends of adenocarcinoma of the cervix by birth cohort. METHODS: Using Surveillance, Epidemiology, and End Results (SEER) data through 1990, the current study is designed to examine the time trends of invasive adenocarcinoma by birth cohort. An age-period-cohort model was fitted to the annual-age-specific rates to identify the components of birth cohort and time period as determinants of the observed time trends. RESULTS: The results from this study clearly show that invasive adenocarcinoma of the uterine cervix has been increasing in both whites and blacks, but the increase is statistically significant only among whites, reaching 4.2 percent per year for those born since 1935. The results also show that the recent increase in invasive adenocarcinoma started among those born around the mid 1920s, and a strong birth cohort effect is largely responsible for the observed increase. CONCLUSION: Invasive adenocarcinoma of the uterine cervix is increasing among recent birth cohorts. Analytical epidemiological studies are urgently needed to explore the risk factors responsible for the increase. The time trends for adenocarcinoma of the cervix should also be carefully monitored in the coming years.
T Zheng; T R Holford; Z Ma; Y Chen; W Liu; B A Ward; P Boyle
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of epidemiology     Volume:  25     ISSN:  0300-5771     ISO Abbreviation:  Int J Epidemiol     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1997-04-24     Completed Date:  1997-04-24     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7802871     Medline TA:  Int J Epidemiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  252-8     Citation Subset:  IM    
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034, USA.
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MeSH Terms
Adenocarcinoma / epidemiology*
African Americans
Age Distribution
Aged, 80 and over
Cohort Studies
European Continental Ancestry Group
Middle Aged
Regression Analysis
Risk Factors
SEER Program
United States / epidemiology
Uterine Cervical Neoplasms / epidemiology*
Grant Support

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