| The continuing development of gastric acid pump inhibitors. | |
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MedLine Citation:
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PMID: 8387826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synthesis and action of H2-receptor antagonists changed the understanding of gastric acid secretion as well as changing medical therapy for peptic ulcer disease. It is now known that peripheral regulation of gastric acid secretion depends largely, but not entirely, on histamine release from the enterochromaffin-like cell. There is, therefore, no final common pathway for stimulation of the parietal cell. In contrast, all stimuli converge to activate the acid pump, the H+,K(+)-ATPase. Inhibition of this pump by clinically useful drugs was achieved by developing derivatives of timoprazole, pyridyl-2-methylsulfinyl benzimidazole. Two of these derivatives, omeprazole and lansoprazole, have shown superiority in acid control and therefore in therapy for peptic ulcer disease compared to the available H2-receptor antagonists. |
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Authors:
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G Sachs; J M Shin; M Besancon; C Prinz |
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Publication Detail:
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Type: Comparative Study; Journal Article; Review |
Journal Detail:
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Title: Alimentary pharmacology & therapeutics Volume: 7 Suppl 1 ISSN: 0269-2813 ISO Abbreviation: Aliment. Pharmacol. Ther. Publication Date: 1993 |
Date Detail:
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Created Date: 1993-06-17 Completed Date: 1993-06-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 4-12, discussion 29-31 Citation Subset: IM |
Affiliation:
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UCLA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Ulcer Agents
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pharmacology Gastric Acid / secretion* H(+)-K(+)-Exchanging ATPase / antagonists & inhibitors* Humans Macromolecular Substances |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Macromolecular Substances; EC 3.6.1.10/H(+)-K(+)-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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