| A contact lens with embedded sensor for monitoring tear glucose level. | |
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MedLine Citation:
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PMID: 21257302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the design, construction, and testing of a contact lens with an integrated amperometric glucose sensor, proposing the possibility of in situ human health monitoring simply by wearing a contact lens. The glucose sensor was constructed by creating microstructures on a polymer substrate, which was subsequently shaped into a contact lens. Titania sol-gel film was applied to immobilize glucose oxidase, and Nafion® was used to decrease several potential interferences (ascorbic acid, lactate, and urea) present in the tear film. The sensor exhibits a fast response (20s), a high sensitivity (240 μA cm(-2) mM(-1)) and a good reproducibility after testing a number of sensors. It shows good linearity for the typical range of glucose concentrations in the tear film (0.1-0.6 mM), and acceptable accuracy in the presence of interfering agents. The sensor can attain a minimum detection of less than 0.01 mM glucose. |
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Authors:
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Huanfen Yao; Angela J Shum; Melissa Cowan; Ilkka Lähdesmäki; Babak A Parviz |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-12-31 |
Journal Detail:
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Title: Biosensors & bioelectronics Volume: 26 ISSN: 1873-4235 ISO Abbreviation: Biosens Bioelectron Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-22 Completed Date: 2011-06-06 Revised Date: 2012-03-19 |
Medline Journal Info:
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Nlm Unique ID: 9001289 Medline TA: Biosens Bioelectron Country: England |
Other Details:
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Languages: eng Pagination: 3290-6 Citation Subset: IM |
Copyright Information:
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Published by Elsevier B.V. |
Affiliation:
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Department of Electrical Engineering, University of Washington, Seattle, WA 98195, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biosensing Techniques
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instrumentation* Contact Lenses* Enzymes, Immobilized / metabolism Equipment Design Glucose / analysis*, metabolism Glucose Oxidase / metabolism Humans Sensitivity and Specificity Tears / chemistry*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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7 P50HG002360-10/HG/NHGRI NIH HHS; P50 HG002360-09/HG/NHGRI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Enzymes, Immobilized; 50-99-7/Glucose; EC 1.1.3.4/Glucose Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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