Document Detail

A contact investigation of the transmission of Mycobacterium tuberculosis from a nurse working in a newborn nursery and maternity ward.
MedLine Citation:
PMID:  18297454     Owner:  NLM     Status:  MEDLINE    
A nurse working in a newborn nursery and maternity ward developed 3+ smear-positive lung tuberculosis. The hospital infection control committee, in collaboration with the local public health and welfare center, conducted a contact investigation. The infection period was defined as April to August 2006. The investigation included 109 infant and mother pairs, 28 children aged under 10 years and their guardians, 62 coworkers, and 63 household visitors to the ward. Tuberculosis infection in infants and children aged under 5 years was primarily determined by tuberculin skin test (TST), while subjects aged 5 years or more were tested using QuantiFERON-TB Gold (QFT). The first investigation, in August 2006, was conducted in all subjects, and the second investigation, in October 2006, targeted selected subjects. No infants were TST-positive. Two children aged 1 year or under, vaccinated with bacillus Calmette-Guérin, were positive for TST, as determined by the criteria of the Japan Anti-Tuberculosis Association; however, other tests for tuberculosis were negative. Of the 13 QFT-positive adult subjects, 1 mother and 2 coworkers could have become infected with Mycobacterium tuberculosis through exposure to the index nurse. Fifty-four infants and 6 children underwent "window-period" prophylaxis, and 4 adults completed 6-month prophylactic treatment with isoniazid. To date, no secondary cases of tuberculosis disease have occurred.
Hitoshi Ohno; Yumiko Ikegami; Kenji Kishida; Yoshiaki Yamamoto; Nobuaki Ikeda; Takashi Taniguchi; Takeshi Ikeda; Atsuo Sato; Takuya Kurasawa; Ken Miyanomae;
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Publication Detail:
Type:  Journal Article     Date:  2008-02-24
Journal Detail:
Title:  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy     Volume:  14     ISSN:  1341-321X     ISO Abbreviation:  J. Infect. Chemother.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-04-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9608375     Medline TA:  J Infect Chemother     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  66-71     Citation Subset:  IM    
Department of Internal Medicine, Takeda General Hospital, 28-1 Ishida, Mori-minami-cho, Fushimi-ku, Kyoto, Japan.
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MeSH Terms
Child, Preschool
Contact Tracing*
Health Personnel
Infant, Newborn
Infectious Disease Transmission, Professional-to-Patient*
Middle Aged
Mycobacterium tuberculosis / isolation & purification,  pathogenicity*
Tuberculin Test
Tuberculosis / epidemiology,  transmission*

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