| A constrained mixture model for developing mouse aorta. | |
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MedLine Citation:
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PMID: 21046424 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Mechanical stresses influence the structure and function of adult and developing blood vessels. When these stresses are perturbed, the vessel wall remodels to return the stresses to homeostatic levels. Constrained mixture models have been used to predict remodeling of adult vessels in response to step changes in blood pressure, axial length and blood flow, but have not yet been applied to developing vessels. Models of developing blood vessels are complicated by continuous and simultaneous changes in the mechanical forces. Understanding developmental growth and remodeling is important for treating human diseases and designing tissue-engineered blood vessels. This study presents a constrained mixture model for postnatal development of mouse aorta with multiple step increases in pressure, length and flow. The baseline model assumes that smooth muscle cells (SMCs) in the vessel wall immediately constrict or dilate the inner radius after a perturbation to maintain the shear stress and then remodel the wall thickness to maintain the circumferential stress. The elastin, collagen and SMCs have homeostatic stretch ratios and passive material constants that do not change with developmental age. The baseline model does not predict previously published experimental data. To approximate the experimental data, it must be assumed that the SMCs dilate a constant amount, regardless of the step change in mechanical forces. It must also be assumed that the homeostatic stretch ratios and passive material constants change with age. With these alterations, the model approximates experimental data on the mechanical properties and dimensions of aorta from 3- to 30-day-old mice. |
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Authors:
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Jessica E Wagenseil |
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Publication Detail:
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Type: Journal Article Date: 2010-11-03 |
Journal Detail:
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Title: Biomechanics and modeling in mechanobiology Volume: 10 ISSN: 1617-7940 ISO Abbreviation: Biomech Model Mechanobiol Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135325 Medline TA: Biomech Model Mechanobiol Country: Germany |
Other Details:
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Languages: eng Pagination: 671-87 Citation Subset: IM; S |
Affiliation:
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Department of Biomedical Engineering, Saint Louis University, 3507 Lindell Blvd., St. Louis, MO, 63110, USA, jwagense@slu.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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