Document Detail


On constitutive descriptors of the biaxial mechanical behaviour of human abdominal aorta and aneurysms.
MedLine Citation:
PMID:  20659928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The abdominal aorta (AA) in older individuals can develop an aneurysm, which is of increasing concern in our ageing population. The structural integrity of the ageing aortic wall, and hence aneurysm, depends primarily on effective elastin and multiple families of oriented collagen fibres. In this paper, we show that a structurally motivated phenomenological 'four-fibre family' constitutive relation captures the biaxial mechanical behaviour of both the human AA, from ages less than 30 to over 60, and abdominal aortic aneurysms. Moreover, combining the statistical technique known as non-parametric bootstrap with a modal clustering method provides improved confidence intervals for estimated best-fit values of the eight associated constitutive parameters. It is suggested that this constitutive relation captures the well-known loss of structural integrity of elastic fibres owing to ageing and the development of abdominal aneurysms, and that it provides important insight needed to construct growth and remodelling models for aneurysms, which in turn promise to improve our ability to predict disease progression.
Authors:
J Ferruzzi; D A Vorp; J D Humphrey
Related Documents :
3985798 - Recurrent aneurysms and late vascular complications following repair of abdominal aorti...
2867268 - Audit of surgical audit.
10195478 - Acute abdominal pain and urgency to defecate in the young and the old: a useful symptom...
12704528 - Infrarenal rupture of an abdominal aortic aneurysm, previously repaired using an endoan...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-07-21
Journal Detail:
Title:  Journal of the Royal Society, Interface / the Royal Society     Volume:  8     ISSN:  1742-5662     ISO Abbreviation:  J R Soc Interface     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-01-25     Completed Date:  2011-04-25     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101217269     Medline TA:  J R Soc Interface     Country:  England    
Other Details:
Languages:  eng     Pagination:  435-50     Citation Subset:  IM    
Affiliation:
Dipartimento di Ingegneria Meccanica Nucleare e della Produzione, Università di Pisa, Pisa, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aging*
Aorta, Abdominal / pathology,  physiopathology*
Aortic Aneurysm, Abdominal / pathology,  physiopathology*
Elasticity
Humans
Models, Cardiovascular*
Grant Support
ID/Acronym/Agency:
HL-86418/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of different modes of viral spread on the dynamics of multiply infected cells in human immuno...
Next Document:  Prediction of feather damage in laying hens using optical flows and Markov models.