Document Detail


A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster.
MedLine Citation:
PMID:  23038734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In mammalian cells, hydrogen peroxide (H(2)O(2))-induced adaptation to oxidative stress is strongly dependent on an Nrf2 transcription factor-mediated increase in the 20S proteasome. Here, we report that both Caenorhabditis elegans nematode worms and Drosophila melanogaster fruit flies are also capable of adapting to oxidative stress with H(2)O(2) pre-treatment. As in mammalian cells, this adaptive response in worms and flies involves an increase in proteolytic activity and increased expression of the 20S proteasome, but not of the 26S proteasome. We also found that the increase in 20S proteasome expression in both worms and flies, as in mammalian cells, is important for the adaptive response, and that it is mediated by the SKN-1 and CNC-C orthologs of the mammalian Nrf2 transcription factor, respectively. These studies demonstrate that stress mechanisms operative in cell culture also apply in disparate intact organisms across a wide biological diversity.
Authors:
Andrew M Pickering; Trisha A Staab; John Tower; Derek Sieburth; Kelvin J A Davies
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Publication Detail:
Type:  Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-04
Journal Detail:
Title:  The Journal of experimental biology     Volume:  216     ISSN:  1477-9145     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-07-10     Revised Date:  2014-02-25    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  543-53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological* / drug effects
Animals
Caenorhabditis elegans / drug effects,  physiology*
Caenorhabditis elegans Proteins / metabolism
Cell Nucleus / drug effects,  metabolism
DNA-Binding Proteins / metabolism
Drosophila Proteins / metabolism
Drosophila melanogaster / drug effects,  physiology*
Female
Gene Knockdown Techniques
Hydrogen Peroxide / pharmacology
Male
Mammals / physiology*
NF-E2-Related Factor 2 / metabolism*
Oxidative Stress* / drug effects
Proteasome Endopeptidase Complex / metabolism*
Protein Transport / drug effects
Proteolysis / drug effects
Survival Analysis
Transcription Factors / metabolism
Grant Support
ID/Acronym/Agency:
3R01-ES 003598-22S2/ES/NIEHS NIH HHS; AG011833/AG/NIA NIH HHS; NS071085-02/NS/NINDS NIH HHS; R01 AG011833/AG/NIA NIH HHS; R01 ES003598/ES/NIEHS NIH HHS; R01 NS071085/NS/NINDS NIH HHS; R01-ES003598/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/NF-E2-Related Factor 2; 0/Transcription Factors; 148733-36-2/skn-1 protein, C elegans; BBX060AN9V/Hydrogen Peroxide; EC 3.4.25.1/Proteasome Endopeptidase Complex
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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