Document Detail

The conserved nucleotide sequences of Bkm, which define Sxr in the mouse, are transcribed.
MedLine Citation:
PMID:  6420069     Owner:  NLM     Status:  MEDLINE    
We have recovered a conserved transcribed component of the snake W chromosome satellite DNA (Bkm) from Drosophila and male mouse libraries. This consists of repeats of the tetranucleotide GATA that are concentrated in the sex-determining region of the Y chromosome of mouse, on the W chromosome of snakes, and in the proximal region of the X chromosome of D. melanogaster, and it appears to be transcribed in a sex-specific and developmentally regulated manner. Sequencing studies show that, unlike most other transcribed repeats, the GATA repeats potentially contain open reading frames. These encode mainly the amino acids leucine, serine, isoleucine, and tyrosine but with occasional variant codons that differ in different clonal isolates. Transcription is exclusive to the GATA strand in different tissues of the same organism and in different unrelated organisms. The complementary strand CTAT contains stop codons in all reading frames. The possible developmental significance of these sequences is discussed.
L Singh; C Phillips; K W Jones
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell     Volume:  36     ISSN:  0092-8674     ISO Abbreviation:  Cell     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-03-02     Completed Date:  1984-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  111-20     Citation Subset:  IM    
Data Bank Information
Bank Name/Acc. No.:
GENBANK/K01664;  K01665;  K01666
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MeSH Terms
Amino Acids / genetics
DNA, Satellite / genetics
Drosophila melanogaster
Nucleic Acid Hybridization
Repetitive Sequences, Nucleic Acid*
Sex Chromosomes*
Sex Determination (Analysis)*
Testosterone / pharmacology
Transcription, Genetic*
Reg. No./Substance:
0/Amino Acids; 0/Codon; 0/DNA, Satellite; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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