Document Detail


A conserved dedicated olfactory circuit for detecting harmful microbes in Drosophila.
MedLine Citation:
PMID:  23217715     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Flies, like all animals, need to find suitable and safe food. Because the principal food source for Drosophila melanogaster is yeast growing on fermenting fruit, flies need to distinguish fruit with safe yeast from yeast covered with toxic microbes. We identify a functionally segregated olfactory circuit in flies that is activated exclusively by geosmin. This microbial odorant constitutes an ecologically relevant stimulus that alerts flies to the presence of harmful microbes. Geosmin activates only a single class of sensory neurons expressing the olfactory receptor Or56a. These neurons target the DA2 glomerulus and connect to projection neurons that respond exclusively to geosmin. Activation of DA2 is sufficient and necessary for aversion, overrides input from other olfactory pathways, and inhibits positive chemotaxis, oviposition, and feeding. The geosmin detection system is a conserved feature in the genus Drosophila that provides flies with a sensitive, specific means of identifying unsuitable feeding and breeding sites. PAPERFLICK:
Authors:
Marcus C Stensmyr; Hany K M Dweck; Abu Farhan; Irene Ibba; Antonia Strutz; Latha Mukunda; Jeanine Linz; Veit Grabe; Kathrin Steck; Sofia Lavista-Llanos; Dieter Wicher; Silke Sachse; Markus Knaden; Paul G Becher; Yoichi Seki; Bill S Hansson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell     Volume:  151     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1345-57     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Evolutionary Neuroethology, Max Planck Institute for Chemical Ecology, Hans-Knöll-Strasse 8, 07745 Jena, Germany. Electronic address: mstensmyr@ice.mpg.de.
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