| The conserved UL24 family of human alpha, beta and gamma herpesviruses induces cell cycle arrest and inactivation of the cyclinB/cdc2 complex. | |
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MedLine Citation:
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PMID: 19526192 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The conserved murine gammaherpesvirus 68 ORF20 has recently been demonstrated to induce G2 cell cycle arrest followed by apoptosis in human and mouse cells. Here, we demonstrate that its homologues UL24 in HSV-1, ORF20 in KSHV and UL76 in HCMV are also inducers of cell cycle arrest followed by apoptosis in both human and mouse cells. The mechanism of action is similar to that reported for MHV-68 ORF20, inactivating the mitotic complex cyclinB/Cdc2. |
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Authors:
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R Nascimento; J D Dias; R M E Parkhouse |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-13 |
Journal Detail:
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Title: Archives of virology Volume: 154 ISSN: 1432-8798 ISO Abbreviation: Arch. Virol. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-07-06 Completed Date: 2009-07-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506870 Medline TA: Arch Virol Country: Austria |
Other Details:
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Languages: eng Pagination: 1143-9 Citation Subset: IM |
Affiliation:
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Instituto Gulbenkian de Ciência, Oeiras, Portugal. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3T3 Cells
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cytology Alphaherpesvirinae / genetics* Animals Betaherpesvirinae / genetics* Cell Cycle Cell Line Conserved Sequence Cyclin B / physiology Gammaherpesvirinae / genetics* Gene Expression Regulation, Viral Genes, Reporter Green Fluorescent Proteins / genetics Herpesvirus 8, Human / genetics Humans Mice Multigene Family Open Reading Frames T-Lymphocytes / cytology Viral Proteins / genetics* |
| Chemical | |
Reg. No./Substance:
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0/CDC2 protein, human; 0/Cyclin B; 0/UL24 protein, Human herpesvirus 1; 0/Viral Proteins; 147336-22-9/Green Fluorescent Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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