Document Detail

The consequences of using inadequate testers in the simplified triple test-cross.
MedLine Citation:
PMID:  268314     Owner:  NLM     Status:  MEDLINE    
The genetical consequences of common alleles in the L1 and L2 testers of a simplified version of the triple test-cross which is applicable to populations of inbred lines are examined. The test for epistasis under these circumstances becomes ambiguous and can spuriously detect non-allelic interactions when they may not exist although it still provides a test for epistasis and the adequacy of the testers simultaneously. The tests of significance and the estimates of additive variation are biased to an extent related to the dominance and dominance x additive effects of the common loci while the significance and estimates of dominance variation are deflated because they reflect the dominance effects at the non-common loci only. The covariance of sums and differences is also underestimated for the same reasons. These expectations are illustrated by analysing the 190 simplified triple test-crosses that could be extracted from a 20 x 20 diallel set of crosses between pure-breeding lines of Nicotiana rustica.
D S Virk; J L Jinks
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heredity     Volume:  38     ISSN:  0018-067X     ISO Abbreviation:  Heredity     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-10-28     Completed Date:  1977-10-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0373007     Medline TA:  Heredity     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  237-51     Citation Subset:  IM    
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MeSH Terms
Crosses, Genetic*
Genes, Dominant
Linkage (Genetics)

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