| The consequences for live kidney donors with preexisting glucose intolerance without diabetic complication: analysis at a single Japanese center. | |
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MedLine Citation:
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PMID: 20535851 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Because of lack of deceased donors in Japan, there has been a need to expand the eligibility criteria for live kidney donation. To assess the indications for live kidney donation in glucose intolerance (GI), we analyzed perioperative complications associated with donor nephrectomies performed at our institution and followed up the long-term consequences. METHODS: The 444 live kidney donors were divided into two groups based on the results of the 75-g oral glucose tolerance test: a GI group (n=71) who showed a diabetic (n=27) or impaired glucose tolerance (n=44) pattern, and a non-GI group (n=373) who showed a normal oral glucose tolerance test pattern. Perioperative complications, longterm survival rate, and frequencies of hypertension, diabetes, hyperlipidemia, and renal dysfunction in long term were compared in each group. RESULTS: The incidence of perioperative complications was not higher in the GI group than in the non-GI group (4.3% vs. 5.4%, respectively; NS). Survival rates in the GI group at 5, 10, and 20 years were 98.3%, 95.1%, and 89.2%, respectively, whereas those in the non-GI group were 98.0%, 96.1%, and 91.5%, thus showing equivalent mortality. None of the patients in the diabetes mellitus group had developed severe diabetic complications or end-stage renal disease at a mean follow-up point of 88+/-71 (range, 14-225) months. CONCLUSIONS: Our results suggest that individuals who have GI without diabetic complication may be able to donate their kidney safely with little surgical complication and little major morbidity if strict evaluation is performed before transplant. |
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Authors:
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Masahiko Okamoto; Tomoyuki Suzuki; Masato Fujiki; Shuji Nobori; Hidetaka Ushigome; Seisuke Sakamoto; Norio Yoshimura |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transplantation Volume: 89 ISSN: 1534-6080 ISO Abbreviation: Transplantation Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-09 Completed Date: 2010-07-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: United States |
Other Details:
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Languages: eng Pagination: 1391-5 Citation Subset: IM |
Affiliation:
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Department of Organ Interaction Research Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, Japan. amoto@koto.kpu-m.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Body Mass Index Diabetes Mellitus / epidemiology Female Follow-Up Studies Glucose Intolerance / epidemiology* Humans Hypertension / epidemiology Japan Kidney Transplantation / physiology* Living Donors* Male Middle Aged Nephrectomy* Patient Selection Retrospective Studies Tissue and Organ Procurement / statistics & numerical data* Treatment Outcome Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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