| The consequences of intravenous clofibrate and its implications in the treatment of fat embolism. | |
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MedLine Citation:
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PMID: 7206007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intravenously administered clofibrate has previously been used in treating experimental fat embolism. In the present study, this procedure was found to produce a syndrome identical to classical experimental fat embolism syndrome. Following the intravenous injection of clofibrate, and the lungs of rats became hemorrhagic and edematous (increased weight) and contained fat globules (clofibrate emboli) when observed microscopically. Dosages of 100 to 0.88305 mul/100 gm body weight produced symptoms ranging from acute death due to massive embolism of lungs to a subclinical fat (clofibrate) embolism syndrome. |
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Authors:
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J C McPherson; T R Dirksen; J C Howard |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of trauma Volume: 21 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 1981 Feb |
Date Detail:
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Created Date: 1981-05-21 Completed Date: 1981-05-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 157-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Clofibrate / administration & dosage, adverse effects*, toxicity Dose-Response Relationship, Drug Edema / chemically induced Embolism, Fat / chemically induced*, drug therapy Female Hemorrhage / chemically induced Injections, Intravenous Lung / pathology Lung Diseases / chemically induced Male Organ Size Rats |
| Chemical | |
Reg. No./Substance:
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637-07-0/Clofibrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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