Document Detail

The connexin43 carboxyl terminus and cardiac gap junction organization.
MedLine Citation:
PMID:  21856279     Owner:  NLM     Status:  MEDLINE    
The precise spatial order of gap junctions at intercalated disks in adult ventricular myocardium is thought vital for maintaining cardiac synchrony. Breakdown or remodeling of this order is a hallmark of arrhythmic disease of the heart. The principal component of gap junction channels between ventricular cardiomyocytes is connexin43 (Cx43). Protein-protein interactions and modifications of the carboxyl-terminus of Cx43 are key determinants of gap junction function, size, distribution and organization during normal development and in disease processes. Here, we review data on the role of proteins interacting with the Cx43 carboxyl-terminus in the regulation of cardiac gap junction organization, with particular emphasis on Zonula Occludens-1. The rapid progress in this area suggests that in coming years we are likely to develop a fuller understanding of the molecular mechanisms causing pathologic remodeling of gap junctions. With these advances come the promise of novel approach to the treatment of arrhythmia and the prevention of sudden cardiac death. This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics.
Joseph A Palatinus; J Matthew Rhett; Robert G Gourdie
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-08-09
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1818     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-06-04     Completed Date:  2013-04-02     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1831-43     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
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MeSH Terms
Amino Acid Sequence
Arrhythmias, Cardiac / therapy
Connexin 43 / chemistry*,  metabolism
Death, Sudden, Cardiac / prevention & control
Gap Junctions / physiology*
Heart Ventricles / metabolism
Models, Molecular
Molecular Sequence Data
Myocardium / metabolism*
Protein Binding
Protein Interaction Mapping / methods
Protein Structure, Tertiary
Tight Junctions / metabolism
Grant Support
1R01DE019355-01/DE/NIDCR NIH HHS; F30 HL095320/HL/NHLBI NIH HHS; F30 HL095320/HL/NHLBI NIH HHS; F30 HL095320-01/HL/NHLBI NIH HHS; HL082802/HL/NHLBI NIH HHS; R01 DE019355/DE/NIDCR NIH HHS; R01 DE019355-01A2/DE/NIDCR NIH HHS; R01 HL056728/HL/NHLBI NIH HHS; R01 HL056728-03/HL/NHLBI NIH HHS; R01 HL056728-04/HL/NHLBI NIH HHS; R01 HL056728-05/HL/NHLBI NIH HHS; R01 HL056728-06/HL/NHLBI NIH HHS; R01 HL056728-07/HL/NHLBI NIH HHS; R01 HL056728-08/HL/NHLBI NIH HHS; R01 HL056728-09/HL/NHLBI NIH HHS; R01 HL056728-10A2/HL/NHLBI NIH HHS; R01 HL056728-11/HL/NHLBI NIH HHS; R01 HL056728-12/HL/NHLBI NIH HHS; R01 HL082802/HL/NHLBI NIH HHS; R01 HL082802-01/HL/NHLBI NIH HHS; R01 HL082802-02/HL/NHLBI NIH HHS; R01 HL082802-03/HL/NHLBI NIH HHS; R01 HL082802-04/HL/NHLBI NIH HHS; T32 HL007260/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Connexin 43

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