Document Detail

The conjunctive stimuli that cause long-term desensitization also predominantly induce c-Fos and Jun-B in cerebellar Purkinje cells.
MedLine Citation:
PMID:  7693017     Owner:  NLM     Status:  MEDLINE    
Expression of immediate early genes (IEGs) was examined following long-term desensitization of cerebellar Purkinje cells. This form of desensitization, which may underlie synaptic long-term depression (LTD), was evoked by co-administration of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA) and 8-bromo cGMP (8-Br-cGMP). Among the IEGS examined with in situ hybridization and immunohistochemistry, combined application of 8-Br-cGMP and AMPA synergistically enhanced the expression of c-Fos and Jun-B in Purkinje cells. This may suggest a role for active transcriptional complexes such as AP-1 (c-Fos/Jun-B), which could be formed following conjoint inputs to Purkinje cells and which may help to establish cerebellar long-term plasticity.
K Nakazawa; L Karachot; Y Nakabeppu; T Yamamori
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  4     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-22     Completed Date:  1993-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1275-8     Citation Subset:  IM    
Laboratory for Neural Networks, Institute of Physical and Chemical Research (RIKEN), Saitama, Japan.
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MeSH Terms
Base Sequence
Cyclic GMP / analogs & derivatives,  pharmacology
Gene Expression Regulation / drug effects,  physiology*
Genes, Immediate-Early / physiology*
In Situ Hybridization
Molecular Sequence Data
Neuronal Plasticity / physiology*
Purkinje Cells / metabolism*
Rats, Wistar
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / pharmacology
Reg. No./Substance:
31356-94-2/8-bromocyclic GMP; 7665-99-8/Cyclic GMP; 77521-29-0/alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

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