Document Detail


NAC/MEA conjugate: a new potent antioxidant which increases the GSH level in various cell lines.
MedLine Citation:
PMID:  11354374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
I-152 is a prodrug of NAC and MEA with potent pro-GSH effects in human macrophages, astrocytes and lymphocytes. This molecule could be of interest in HIV infection in respect to its antioxidant and anti-HIV activities, but also in other diseases to counteract oxidative stress, that is, inflammation, cardiovascular diseases, and neurodegenerative diseases.
Authors:
J Oiry; P Mialocq; J Y Puy; P Fretier; P Clayette; D Dormont; J L Imbach
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  11     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-16     Completed Date:  2001-10-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  1189-91     Citation Subset:  IM    
Affiliation:
Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-UM II, Université Montpellier II, Sciences et Techniques du Languedoc, France. oiryj@univ-montp2.fr
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / analogs & derivatives,  chemical synthesis*,  pharmacology*
Antioxidants / chemical synthesis*,  pharmacology*
Astrocytes / drug effects,  metabolism
CD4-Positive T-Lymphocytes / drug effects,  metabolism
Cell Line
Cysteamine / analogs & derivatives,  chemical synthesis*,  pharmacology*
Glutathione / metabolism*
HIV Infections / metabolism
Humans
Indicators and Reagents
Macrophages / drug effects,  metabolism
Monocytes / drug effects,  metabolism
Prodrugs / chemical synthesis*,  pharmacology*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/I-152 compound; 0/Indicators and Reagents; 0/Prodrugs; 60-23-1/Cysteamine; 616-91-1/Acetylcysteine; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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