Document Detail

A cone-beam volume CT using a 3D angiography system with a flat panel detector of direct conversion type: usefulness for superselective intra-arterial chemotherapy for head and neck tumors.
MedLine Citation:
PMID:  17885248     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: The development of flat panel detectors (FPDs) has made cone-beam CT feasible for practical use in a clinical setting. Our purpose was to assess the usefulness of cone-beam CT using the FPD in conjunction with conventional digital subtraction angiography (DSA) for performing superselective intra-arterial chemotherapy for head and neck tumors. MATERIALS AND METHODS: Twenty-three consecutive patients (43 feeding arteries) were prospectively examined. All of the patients underwent intra-arterial rotational angiography using an FPD system, and the cone-beam CT was reconstructed from the volume dataset. Two radiologists evaluated the quality of the cone-beam CT and then evaluated whether the additional information provided by the cone-beam CT was useful for the interventional procedures. RESULTS: In 41 (95%) of 43 arteries, the extent of contrast material perfusion was sufficiently visualized on cone-beam CT. In 20 (47%) of 43 arteries, the DSA plus cone-beam CT was superior to the DSA alone regarding the precise understanding of vascular territory of each artery. This information was helpful for predicting the drug delivery for superselective intra-arterial chemotherapy, especially in deeply invasive tumors with multiple feeding arteries. CONCLUSION: In superselective intra-arterial chemotherapy for head and neck tumors, cone-beam CT with FPD provides useful additional information, which allows interventional radiologists to determine the feeders, as well as the dose of antitumor agent for each feeder.
S Kakeda; Y Korogi; Y Miyaguni; J Moriya; N Ohnari; N Oda; K Nishino; W Miyamoto
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2007-09-20
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  28     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-09     Completed Date:  2007-11-26     Revised Date:  2008-02-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1783-8     Citation Subset:  IM    
Department of Radiology, University of Occupational and Environmental Health School of Medicine, Kitakyushu, Japan.
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MeSH Terms
Aged, 80 and over
Angiography, Digital Subtraction / instrumentation*,  methods
Antineoplastic Agents / administration & dosage*
Equipment Design
Equipment Failure Analysis
Feasibility Studies
Head and Neck Neoplasms / drug therapy*,  radiography*
Injections, Intra-Arterial / instrumentation,  methods
Middle Aged
Radiographic Image Enhancement / instrumentation*
Radiography, Interventional / instrumentation
Reproducibility of Results
Sensitivity and Specificity
Tomography, Spiral Computed / instrumentation*
X-Ray Intensifying Screens*
Reg. No./Substance:
0/Antineoplastic Agents

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