| The conditional medaka mutation eyeless uncouples patterning and morphogenesis of the eye. | |
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MedLine Citation:
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PMID: 10751179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In early vertebrate eye development, the retinal anlage is specified in the anterior neuroectoderm. During neurulation, the optic vesicles evaginate from the lateral wall of the prosencephalon. Here we describe the temperature-sensitive mutation eyeless in the Japanese medakafish. Marker gene analysis indicates that, whereas, specification of two retinal primordia and proximodistal patterning takes place in the mutant embryo, optic vesicle evagination does not occur and subsequent differentiation of the retinal primordia is not observed. The mutation eyeless thus uncouples patterning and morphogenesis at early steps of retinal development. Temperature-shift experiments indicate a requirement for eyeless activity prior to optic vesicle evagination. Cell transplantation shows that eyeless acts cell autonomously. |
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Authors:
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S Winkler; F Loosli; T Henrich; Y Wakamatsu; J Wittbrodt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 127 ISSN: 0950-1991 ISO Abbreviation: Development Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-06-15 Completed Date: 2000-06-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1911-9 Citation Subset: IM |
Affiliation:
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Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, PO Box 10.2209, Germany. Wittbrodt@EMBL-Heidelberg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / genetics Body Patterning / genetics* Brain / embryology Cell Division DNA-Binding Proteins / genetics* Drosophila Proteins* Eye / embryology* Eye Proteins Gene Expression Regulation, Developmental Genes, Recessive Homeodomain Proteins* In Situ Hybridization Morphogenesis Mutation Oryzias / embryology*, genetics Paired Box Transcription Factors Plant Proteins / genetics Repressor Proteins Retina / embryology Temperature |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Eye Proteins; 0/Homeodomain Proteins; 0/PAX6 protein; 0/Paired Box Transcription Factors; 0/Plant Proteins; 0/RX2.AC15 protein, Solanum acaule; 0/Repressor Proteins; 0/eyeless protein, Drosophila |
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