Document Detail

On the conditional equivalence of chemical loading and mechanical loading on articular cartilage.
MedLine Citation:
PMID:  9882052     Owner:  NLM     Status:  MEDLINE    
Osmotic pressure loading of articular cartilage has been customarily invoked to be equivalent to mechanical loading. In the literature, this equivalence is defined by the amount of water squeezed from the tissue, i.e. if the amount of water content lost by these two modes of loading are the same, it has been generally regarded that the two loadings are equivalent. This assumption has never been proven. Using the water content lost concept, in this paper, we derived the exact conditions under which an osmotic pressure loading of cartilage can be considered to be equivalent to a mechanical loading. However, the mechanical loading condition satisfying this equivalency criterion, i.e. an isotropic loading delivered via a porous permeable rigid platen uniformly applied all around the specimen, is not practically achievable. Moreover, even if this were achieved experimentally, the interstitial fluid pressure caused by the two loading conditions are not the same. This result has important ramifications for interpretation of experimental data from mechanical stimulations of cartilage explant studies.
W M Lai; W Y Gu; V C Mow
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of biomechanics     Volume:  31     ISSN:  0021-9290     ISO Abbreviation:  J Biomech     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-11     Completed Date:  1999-03-11     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1181-5     Citation Subset:  IM; S    
Department of Mechanical Engineering, Columbia University, New York, NY, USA.
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MeSH Terms
Body Water / chemistry,  physiology
Cartilage, Articular / chemistry,  physiology*
Chemistry, Physical
Chondrocytes / chemistry,  physiology
Extracellular Space / chemistry,  physiology
Hydrostatic Pressure
Osmotic Pressure
Physicochemical Phenomena
Polyethylene Glycols / chemistry
Sodium Chloride / chemistry
Stress, Mechanical
Grant Support
Reg. No./Substance:
0/Polyethylene Glycols; 7647-14-5/Sodium Chloride

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