| A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions. | |
| | |
MedLine Citation:
|
PMID: 22197135 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms. |
| | |
Authors:
|
Guan-Jhong Huang; M Vijaya Bhaskar Reddy; Ping-Chung Kuo; Chieh-Hung Huang; Hung-Cheng Shih; E-Jian Lee; Mei-Lin Yang; Yann-Lii Leu; Tian-Shung Wu |
Related Documents
:
|
11189445 - Tissue-level cytoprotection. 9316215 - Fibrosis, a common pathway to organ failure: angiotensin ii and tissue repair. 12498785 - Macrophages and microglia produce local trophic gradients that stimulate axonal sprouti... 18393925 - Epithelial-mesenchymal transition as a therapeutic target for prevention of ocular tiss... 8765825 - Enhanced nasal cytokine production in human beings after in vivo challenge with diesel ... 16204585 - In vitro studies of lymphangioleiomyomatosis. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-9 |
Journal Detail:
|
Title: European journal of medicinal chemistry Volume: - ISSN: 1768-3254 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0420510 Medline TA: Eur J Med Chem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Masson SAS. All rights reserved. |
Affiliation:
|
School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan, ROC. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Standardization of catheter load speed during embryo transfer: comparison of manual and pump-regulat...
Next Document: Synthesis and structure-activity relationship of 5-pyridazin-3-one phenoxypiperidines as potent, sel...