Document Detail

A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds.
MedLine Citation:
PMID:  23321958     Owner:  NLM     Status:  Publisher    
Historically, chemists' exploration of chemical space has been exceptionally uneven and unsystematic. This feature article outlines a comprehensive conceptual framework that may be used to capture, analyse and plan synthetic approaches that may address this historically uneven exploration. Illustrative examples of synthetic approaches that target, or have potential to target, broad tracts of lead-like chemical space are presented within the context of this conceptual framework. Particular emphasis is placed on synthetic approaches that enable the combinatorial variation of molecular scaffold, particularly within the boundaries of lead-like chemical space.
Paul Maclellan; Adam Nelson
Related Documents :
24707348 - An horizon scan of biogeography.
24657268 - Robust and stable feature selection by integrating ranking methods and wrapper techniqu...
24108268 - Robust inference for mixed censored and binary response models with missing covariates.
24420728 - Is state-trace analysis an appropriate tool for assessing the number of cognitive systems?
9299088 - On the elastic properties of the interfaces that stabilize gas cavitation nuclei
14557098 - Differential weighting of errors on a test of clinical reasoning skills.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Microwave absorption in powders of small conducting particles for heating applications.
Next Document:  A privacy enhanced authentication scheme for telecare medical information systems.