Document Detail


The concept of isoreceptors: application to the nicotinic acetylcholine receptor and the gamma-aminobutyric acidA/benzodiazepine receptor complex.
MedLine Citation:
PMID:  2830362     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concept of isoreceptors offers a possible clue to account for pharmacological and biochemical heterogeneity in specific receptor systems. The existence of isozymes has set the foundation for the definition of isoreceptors. The resulting criteria are applied to two central receptor complexes. Accordingly, the nicotinic acetylcholine receptor is defined as an isoreceptor, and research results on the GABA/benzodiazepine receptor are interpreted under the consideration of the possible existence of isoreceptors.
Authors:
J Hebebrand; W Friedl; P Propping
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neural transmission     Volume:  71     ISSN:  -     ISO Abbreviation:  J. Neural Transm.     Publication Date:  1988  
Date Detail:
Created Date:  1988-03-28     Completed Date:  1988-03-28     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0337042     Medline TA:  J Neural Transm     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Binding Sites
Models, Molecular
Molecular Conformation
Receptors, GABA-A / analysis,  classification*
Receptors, Nicotinic / analysis,  classification*
Chemical
Reg. No./Substance:
0/Receptors, GABA-A; 0/Receptors, Nicotinic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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