| The concept of RNA-assisted protein folding:Representation of Amino Acid Kinetics at the tRNA Level. | |
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MedLine Citation:
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PMID: 23044190 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Transfer RNA molecules (tRNA) have the thermodynamic potential to interact with each other to form dimers (hybridization energy, dG=-33.2±6.7kcal/mole, compared to the folding energy of the cloverleaf configuration, dG=-25±4.4kcal/mole, p<0.0001). The dG values have a strong negative correlation with the frequency of co-locations and substitutions of associated amino acids. We suggest that tRNA interactions participate in determining amino acid interactions (co-locations) and consequently the 3D structures of peptides. |
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Authors:
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Jan C Biro; Josephine Mk Biro |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-5 |
Journal Detail:
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Title: Journal of theoretical biology Volume: - ISSN: 1095-8541 ISO Abbreviation: J. Theor. Biol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376342 Medline TA: J Theor Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Karolinska Institute, Stockholm, Sweden and Homulus Foundation, Los Angeles, CA, USA. Electronic address: jan.biro@att.net. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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