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The concept of RNA-assisted protein folding:Representation of Amino Acid Kinetics at the tRNA Level.
MedLine Citation:
PMID:  23044190     Owner:  NLM     Status:  Publisher    
Transfer RNA molecules (tRNA) have the thermodynamic potential to interact with each other to form dimers (hybridization energy, dG=-33.2±6.7kcal/mole, compared to the folding energy of the cloverleaf configuration, dG=-25±4.4kcal/mole, p<0.0001). The dG values have a strong negative correlation with the frequency of co-locations and substitutions of associated amino acids. We suggest that tRNA interactions participate in determining amino acid interactions (co-locations) and consequently the 3D structures of peptides.
Jan C Biro; Josephine Mk Biro
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-5
Journal Detail:
Title:  Journal of theoretical biology     Volume:  -     ISSN:  1095-8541     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Karolinska Institute, Stockholm, Sweden and Homulus Foundation, Los Angeles, CA, USA. Electronic address:
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