Document Detail

Baló's concentric sclerosis: surviving normal myelin in a patient with a relapsing-remitting dinical course.
MedLine Citation:
PMID:  11795459     Owner:  NLM     Status:  MEDLINE    
Baló's concentric sclerosis is a demyelinating disorder in which bands of demyelination alternate with concentric bands of myelin preservation. The pathogenesis of the lesion is unknown. Previous reports using modern histopathologic techniques have shown the bands of myelin preservation to be comprised of remyelinated or partially demyelinated myelin. Here we report a case of Baló's concentric sclerosis in a 24-year-old East Indian patient with a previous history of relapsing-remitting multiple sclerosis (MS). Pathologically, the bands of myelin preservation showed myelin sheaths of normal thickness, with focal areas of demyelination. The findings, taken together with those of previously reported cases, suggest that Baló's concentric sclerosis is a variant of MS, and the concentric lesion may be an intermediary form in evolution of a chronic active MS plaque. The pathogenesis of this concentric lesion may be explained by periodic suppression of demyelination in the rapidly expanding border, allowing remyelination or only transient incomplete demyelination to occur.
G R Moore; K Berry; J J Oger; A J Prout; D A Graeb; R A Nugent
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Multiple sclerosis (Houndmills, Basingstoke, England)     Volume:  7     ISSN:  1352-4585     ISO Abbreviation:  Mult. Scler.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-01-17     Completed Date:  2002-06-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9509185     Medline TA:  Mult Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  375-82     Citation Subset:  IM    
Department of Pathology and Laboratory Medicine (Neuropathology), Vancouver Hospital and Health Services Centre, BC, Canada.
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MeSH Terms
Brain / pathology
Demyelinating Diseases / pathology
Diffuse Cerebral Sclerosis of Schilder / complications,  diagnosis,  pathology,  physiopathology*
Magnetic Resonance Imaging
Microscopy, Electron
Multiple Sclerosis, Relapsing-Remitting / complications
Myelin Sheath / metabolism*,  pathology
Grant Support

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