Document Detail

The concentration of retinoic acid determines the differentiated cell types formed by a teratocarcinoma cell line.
MedLine Citation:
PMID:  6345235     Owner:  NLM     Status:  MEDLINE    
Retinoic acid (RA) can induce the differentiation of teratocarcinoma cells in culture (S. Strickland and V. Mahdavi, 1978, Cell 15, 393-403; E. M. V. Jones-Villeneuve, M. W. McBurney, K. A. Rogers, and V. I. Kalnins, 1982, J. Cell. Biol. 94, 253-262). With the teratocarcinoma cell line, P19S1801A1 (O1A1), the differentiated cell types formed from cell aggregates exposed to RA are dependent on the concentration of drug used in the treatment. Cultures exposed to low concentrations (10(-9)M) are characterized by an abundance of cardiac muscle. Skeletal muscle becomes abundant at higher drug concentrations (10(-8)M) with neurons and astroglia appearing at very high concentrations (10(-7) to 10(-5) M). These results suggest that during normal embryogenesis, the commitment of pluripotent cells to particular developmental avenues may be determined in part by concentration gradients of substances such as retinoids.
M K Edwards; M W McBurney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental biology     Volume:  98     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  187-91     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation / drug effects
Cell Line
Dose-Response Relationship, Drug
Fluorescent Antibody Technique
Teratoma / pathology*
Tretinoin / pharmacology*
Reg. No./Substance:

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