| The concentration of dopamine, 5-hydroxytryptamine, and some of their acid metabolites in the brain of genetically diabetic rats. | |
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MedLine Citation:
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PMID: 2409457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This is a report of the concentrations of DA, DOPAC, HVA, 5-HT, and 5-HIAA in the brain of spontaneously diabetic male Wistar rats. These rats showed a marked increase in blood and urine glucose, polydipsia, polyuria, and weight loss that had an onset 11-23 days earlier. Controls were litter mates with no hyperglycemia, glucosuria or weight reduction. The spontaneously diabetic rats showed a significant reduction of DOPAC in the striatum, and DOPAC, HVA, and 5HIAA in the olfactory tubercles (to 69, 61, 62, and 65% of their respective controls). No changes were found in the concentrations of DA or 5-HT. Thus the spontaneously diabetic rats showed a marked reduction in striatal and mesolimbic DA and mesolimbic 5-HT metabolism. This reduction in metabolism could be the consequence of a reduction in the formation of DA and 5-HT. |
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Authors:
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R P Kwok; E K Walls; A V Juorio |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurochemical research Volume: 10 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 1985 May |
Date Detail:
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Created Date: 1985-08-22 Completed Date: 1985-08-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 611-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism Animals Brain / drug effects, metabolism* Corpus Striatum / metabolism Diabetes Mellitus, Experimental / metabolism* Dopamine / metabolism Homovanillic Acid / metabolism Hydroxyindoleacetic Acid / metabolism Insulin / pharmacology Male Olfactory Bulb / metabolism Rats Rats, Inbred Strains Serotonin / metabolism* |
| Chemical | |
Reg. No./Substance:
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102-32-9/3,4-Dihydroxyphenylacetic Acid; 11061-68-0/Insulin; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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