Document Detail


A concentration-dependent mechanism by which serum albumin inactivates replacement lung surfactants.
MedLine Citation:
PMID:  11806925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endogenous lung surfactant, and lung surfactant replacements used to treat respiratory distress syndrome, can be inactivated during lung edema, most likely by serum proteins. Serum albumin shows a concentration-dependent surface pressure that can exceed the respreading pressure of collapsed monolayers in vitro. Under these conditions, the collapsed surfactant monolayer can not respread to cover the interface, leading to higher minimum surface tensions and alterations in isotherms and morphology. This is an unusual example of a blocked phase transition (collapsed to monolayer form) inhibiting bioactivity. The concentration-dependent surface activity of other common surfactant inhibitors including fibrinogen and lysolipids correlates well with their effectiveness as inhibitors. These results show that respreading pressure may be as important as the minimum surface tension in the design of replacement surfactants for respiratory distress syndrome.
Authors:
H E Warriner; J Ding; A J Waring; J A Zasadzinski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biophysical journal     Volume:  82     ISSN:  0006-3495     ISO Abbreviation:  Biophys. J.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-24     Completed Date:  2002-04-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  835-42     Citation Subset:  IM    
Affiliation:
Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA.
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MeSH Terms
Descriptor/Qualifier:
Biophysical Phenomena
Biophysics
Dose-Response Relationship, Drug
Fibrinogen / pharmacology
Humans
Immunoglobulin G / metabolism
Infant, Newborn
Lipids / pharmacology
Microscopy, Fluorescence
Pulmonary Surfactants / chemistry*,  pharmacology*
Respiratory Distress Syndrome, Newborn / metabolism
Serum Albumin / pharmacology*
Temperature
Time Factors
Chemical
Reg. No./Substance:
0/Immunoglobulin G; 0/Lipids; 0/Pulmonary Surfactants; 0/Serum Albumin; 9001-32-5/Fibrinogen
Comments/Corrections

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