Document Detail

A computerized analysis of platelet aggregation detected by ultrasound.
MedLine Citation:
PMID:  2675387     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine if computerized image processing could be used to characterize platelet aggregation visualized by ultrasound. Citrated whole blood (WB) or platelet-rich plasma (PRP) was imaged with a 12 mHz transducer before and after the addition of adenosine diphosphate. The images were digitized using a 512 x 512 pixel resolution with 256 levels of gray. Raster interference was eliminated by filtering and aggregates were separated from background by gray level discrimination. The results showed that platelet aggregation in PRP can be described by the number of aggregates counted, their sizes or their gray levels. However, aggregation in WB can be detected only by the sizes or gray levels of the aggregates due to the greater echogenicity of ex vivo WB. This methodology, applied to ultrasonic images of brachial arteries and veins, demonstrates that venous particles are common in patients and normal controls, but arterial particles are more common in patients. Differences in the size and brightness of these particles may have prognostic implications.
C Mahony; J L Elion; P L Fischer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  55     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-10-16     Completed Date:  1989-10-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  351-60     Citation Subset:  IM    
Division of Cardiology, University of Kentucky School of Medicine, Lexington 40536.
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MeSH Terms
Arm / blood supply
Brachial Artery
Image Processing, Computer-Assisted*
Platelet Aggregation*
Ultrasonography / methods*

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