| A computer simulation of conduction in demyelinated nerve fibres. | |
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MedLine Citation:
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PMID: 4675037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The theoretical effects of demyelination on conduction of a propagated impulse have been examined in a computer simulated myelinated nerve fibre. Demyelination was simulated by increasing the capacitance and conductance of the myelin sheath of individual internodes or parts of internodes.2. Internodal conduction time increased as myelin thickness was decreased. The increase in internodal conduction time became more precipitous as the myelin became thinner. Propagation continued past a single demyelinated internode until myelin thickness was uniformly reduced to less than 2.7% of normal myelin thickness.3. Paranodal demyelination was more effective in slowing impulse conduction than was uniform demyelination of an entire internode with an equivalent rise in overall internodal capacitance and conductance.4. The effects on conduction of demyelination of two adjacent internodes or of two internodes separated by a normal internode were more than the sum of the effects of demyelination of each internode individually.5. Propagation across a severely demyelinated internode was blocked with an increase in internal sodium concentration which had a trivial effect on conduction in a normal fibre.6. Propagation across a severely demyelinated internode was blocked with increased temperature at a temperature at which propagation proceeds normally across normal internodes.7. The similarity between the findings of the computer simulations and the experimental findings in demyelinated fibres is discussed. |
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Authors:
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Z J Koles; M Rasminsky |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of physiology Volume: 227 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1972 Dec |
Date Detail:
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Created Date: 1973-03-13 Completed Date: 1973-03-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 351-64 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Amphibians Animals Axons / physiology* Computers Mammals Models, Neurological* Myelin Sheath / physiology* Neural Conduction* Ranvier's Nodes / physiology Sodium / physiology Temperature |
| Chemical | |
Reg. No./Substance:
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7440-23-5/Sodium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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