| A computer model of gas exchange during cardiopulmonary resuscitation. | |
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MedLine Citation:
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PMID: 9783507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper presents a computer model of gas exchange during cardiopulmonary resuscitation (CPR) that permits independent adjustment of inspired air content (16% O2 and 4.5% CO2 present in mouth-to-mouth (MTM) ventilation or ambient air), shunt, deadspace, diffusion impairment, cardiac output, and ventilation. The model contains 15500 acini, each with its own blood supply. Gas exchange occurs at each perfused and ventilated acinus. Arterial P(O2) and P(CO2) are calculated from the summed arterial blood flow using standard formulae. The model and simulations show that MTM ventilation provides inadequate oxygenation when the victim is at high altitude or has diffusion impairment. They also show that analysis of inspired and expired gas concentrations to measure gas exchange primarily measures wash in and wash out of gas when cardiac output is low and that this explains the negative oxygen consumption and carbon dioxide production measured in a previous study. |
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Authors:
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M Engoren; M Plewa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Resuscitation Volume: 38 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-12-22 Completed Date: 1998-12-22 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: IRELAND |
Other Details:
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Languages: eng Pagination: 33-8 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, St. Vincent Mercy Medical Center, Toledo, OH 43608, USA. engoren@pol.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carbon Dioxide
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blood Cardiac Output Cardiopulmonary Resuscitation* Computer Simulation* Humans Lung* Models, Anatomic* Oxygen / blood Partial Pressure Pulmonary Gas Exchange* Respiratory Dead Space Software Time Factors |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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