Document Detail


A computational study of the respiratory airflow characteristics in normal and obstructed human airways.
MedLine Citation:
PMID:  25058489     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Obstructive lung diseases in the lower airways are a leading health concern worldwide. To improve our understanding of the pathophysiology of lower airways, we studied airflow characteristics in the lung between the 8th and the 14th generations using a three-dimensional computational fluid dynamics model, where we compared normal and obstructed airways for a range of breathing conditions. We employed a novel technique based on computing the Pearson׳s correlation coefficient to quantitatively characterize the differences in airflow patterns between the normal and obstructed airways. We found that the airflow patterns demonstrated clear differences between normal and diseased conditions for high expiratory flow rates (>2300ml/s), but not for inspiratory flow rates. Moreover, airflow patterns subjected to filtering demonstrated higher sensitivity than airway resistance for differentiating normal and diseased conditions. Further, we showed that wall shear stresses were not only dependent on breathing rates, but also on the distribution of the obstructed sites in the lung: for the same degree of obstruction and breathing rate, we observed as much as two-fold differences in shear stresses. In contrast to previous studies that suggest increased wall shear stress due to obstructions as a possible damage mechanism for small airways, our model demonstrated that for flow rates corresponding to heavy activities, the wall shear stress in both normal and obstructed airways was <0.3Pa, which is within the physiological limit needed to promote respiratory defense mechanisms. In summary, our model enables the study of airflow characteristics that may be impractical to assess experimentally.
Authors:
Bora Sul; Anders Wallqvist; Michael J Morris; Jaques Reifman; Vineet Rakesh
Related Documents :
22719759 - Reconstruction of exposure to m-xylene from human biomonitoring data using pbpk modelli...
17744469 - Life cycle, individual thrift, and the wealth of nations.
16615039 - Deleting 'irrational' responses from discrete choice experiments: a case of investigati...
19756899 - Why dichotomies can be misleading while dualities fit the analysis of complex phenomena.
15808889 - Assessing the predictive value of means-end-chain theory: an application to meat produc...
23566399 - Svm-based feature selection to optimize sensitivity-specificity balance applied to wean...
12444739 - Cyclical conjunction: an efficient operator for the extraction of cycles from a graph.
24984569 - The application of allometric scaling principles to predict pharmacokinetic parameters ...
23935779 - Correction: edge principal components and squash clustering: using the special structur...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-25
Journal Detail:
Title:  Computers in biology and medicine     Volume:  52C     ISSN:  1879-0534     ISO Abbreviation:  Comput. Biol. Med.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-7-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1250250     Medline TA:  Comput Biol Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  130-143     Citation Subset:  -    
Copyright Information:
Published by Elsevier Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Large carbon dioxide fluxes from headwater boreal and sub-boreal streams.
Next Document:  Harbor Seals (Phoca vitulina) Can Perceive Optic Flow under Water.