Document Detail

A computational study of multisensory maturation in the superior colliculus (SC).
MedLine Citation:
PMID:  21556818     Owner:  NLM     Status:  MEDLINE    
Multisensory neurons in cat SC exhibit significant postnatal maturation. The first multisensory neurons to appear have large receptive fields (RFs) and cannot integrate information across sensory modalities. During the first several months of postnatal life RFs contract, responses become more robust and neurons develop the capacity for multisensory integration. Recent data suggest that these changes depend on both sensory experience and active inputs from association cortex. Here, we extend a computational model we developed (Cuppini et al. in Front Integr Neurosci 22: 4-6, 2010) using a limited set of biologically realistic assumptions to describe how this maturational process might take place. The model assumes that during early life, cortical-SC synapses are present but not active and that responses are driven by non-cortical inputs with very large RFs. Sensory experience is modeled by a "training phase" in which the network is repeatedly exposed to modality-specific and cross-modal stimuli at different locations. Cortical-SC synaptic weights are modified during this period as a result of Hebbian rules of potentiation and depression. The result is that RFs are reduced in size and neurons become capable of responding in adult-like fashion to modality-specific and cross-modal stimuli.
Cristiano Cuppini; Barry E Stein; Benjamin A Rowland; Elisa Magosso; Mauro Ursino
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-05-10
Journal Detail:
Title:  Experimental brain research     Volume:  213     ISSN:  1432-1106     ISO Abbreviation:  Exp Brain Res     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-08-12     Completed Date:  2011-12-15     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  341-9     Citation Subset:  IM    
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MeSH Terms
Action Potentials
Animals, Newborn
Brain Mapping*
Learning / physiology
Models, Biological*
Neurons / physiology*
Perception / physiology*
Physical Stimulation
Superior Colliculi / cytology*,  growth & development*
Grant Support
EY016716/EY/NEI NIH HHS; NS036916/NS/NINDS NIH HHS; R01 EY016716/EY/NEI NIH HHS; R01 EY016716-04/EY/NEI NIH HHS; R01 NS036916/NS/NINDS NIH HHS; R01 NS036916-24/NS/NINDS NIH HHS

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