Document Detail

A computational study of the factors influencing pressure 
in arteriovenous fistulae venous aneurysms.
MedLine Citation:
PMID:  23599139     Owner:  NLM     Status:  Publisher    
<b>Purpose: </b>To investigate<b> </b>the factors influencing the hydrostatic pressure exerted within the venous aneurysms (VA) of an arteriovenous fistula (AVF). <b>Methods:</b> Ideal models of a side-to-end brachial-cephalic AVF were computationally constructed and typical values for the length and the local diameters were considered for both the artery and vein sections of the models. Three VA configurations were reconstructed (spherical, fusiform and curved) and hydrostatic pressure was assessed with respect to different degrees of the outflow vein stenosis, ranging from 25% to 95%, and VA maximum diameters, using validated, commercially available software.<b>Results: </b>The pressure in the VA was steady (1200 Pa) for venous outflow stenoses up to 75%. For stenoses greater than 75% a exponential pressure rise was observed, reaching 1500 Pa for stenoses of 95%. Neither the VA configuration nor its maximum diameter affected the pressure values exerted within the VA or the point of the pressure upstroke.<b>Conclusions:</b> our study supports the presence of a critical stenotic outflow vein diameter beyond which there is an exponential VA pressure increase, influenced neither by the shape nor the size of the VA. Whether the prompt, non-invasive detection of this finding can contribute or lead to the determination of a criterion for early intervention in VAs before clinical complications are developed, should be investigated by future studies.
Efstratios I Georgakarakos; Antonios Xenakis; Konstantinos C Kapoulas; Sokrates Tsangaris; George S Georgiadis; Miltos K Lazarides
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-9
Journal Detail:
Title:  The journal of vascular access     Volume:  0     ISSN:  1724-6032     ISO Abbreviation:  J Vasc Access     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100940729     Medline TA:  J Vasc Access     Country:  -    
Other Details:
Languages:  ENG     Pagination:  0     Citation Subset:  -    
Department of Vascular Surgery, "Democritus" University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis - Greece.
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