Document Detail


A computational model to determine energy intake during weight loss.
MedLine Citation:
PMID:  20962159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Energy intake (EI) during weight loss is difficult and costly to measure accurately.
OBJECTIVE: The objective was to develop and validate a computational energy balance differential equation model to determine individual EI during weight loss.
DESIGN: An algorithm was developed to quantify EI during weight loss based on a validated one-dimensional model for weight change. By using data from a 24-wk calorie-restriction study, we tested the validity of the EI model against 2 criterion measures: 1) EI quantified through food provision from weeks 0-4 and 4-12 and 2) EI quantified through changes in body energy stores [measured with dual-energy X-ray absorptiometry (DXA)] and energy expenditure [measured with doubly labeled water (DLW)] from weeks 4-12 and 12-24.
RESULTS: Compared with food provision, the mean (±SD) model errors were 41 ± 118 kcal/d and -22 ± 230 kcal/d from weeks 0-4 and 4-12, respectively. Compared with EI measured with DXA and DLW, the model errors were -71 ± 272 kcal/d and -48 ± 226 kcal/d from weeks 4-12 and 12-24, respectively. In every comparison, the mean error was never significantly different from zero (P values > 0.10). Furthermore, Bland and Altman analysis indicated that error variance did not differ significantly over amounts of EI (P values > 0.26). Almost all individual participants' values were within CI limits.
CONCLUSION: The validity of the newly developed EI model was supported by experimental observations and can be used to determine an individual participant's EI during weight loss.
Authors:
Diana M Thomas; Dale A Schoeller; Leanne A Redman; Corby K Martin; James A Levine; Steven B Heymsfield
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Studies     Date:  2010-10-20
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  92     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2010-12-23     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1326-31     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Adult
Algorithms
Caloric Restriction
Energy Intake / physiology*
Energy Metabolism / physiology*
Female
Humans
Male
Models, Biological*
Weight Loss / physiology*
Grant Support
ID/Acronym/Agency:
DK56650/DK/NIDDK NIH HHS; DK63226/DK/NIDDK NIH HHS; DK662760/DK/NIDDK NIH HHS; K23 DK068052/DK/NIDDK NIH HHS; K99 HD060762/HD/NICHD NIH HHS; K99 HD060762/HD/NICHD NIH HHS; K99 HD060762-01A1/HD/NICHD NIH HHS; M01 RR00585/RR/NCRR NIH HHS; P01 AG11915/AG/NIA NIH HHS; R00 HD060762/HD/NICHD NIH HHS; U01 AG20478/AG/NIA NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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