Document Detail

On computational control of flow in airblast atomisers for pulmonary drug delivery.
MedLine Citation:
PMID:  12052688     Owner:  NLM     Status:  MEDLINE    
Among different approaches to successful pharmacotherapy the pulmonary drug delivery (PDD) mode plays an increasingly important role. In this paper PDD systems based on air-blast atomisation have been analysed mathematically. In order to allow the bioengineer to estimate the degree of effectiveness of a specific system prototype and to lay the basic principles for design, a conservation-law-based mathematical model is discussed. Key control parameters that allow improvement in the efficiency of the system have been identified and main characteristics of the system have been analysed numerically as functions of these parameters.
R V N Melnik; David R Jenkins
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  239     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-07     Completed Date:  2002-07-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  23-35     Citation Subset:  IM    
University of Southern Denmark, Mads Clausen Institute, Grundtvigs Alle 150, Sonderborg DK-6400, Denmark.
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MeSH Terms
Aerosol Propellants
Computer Simulation
Drug Delivery Systems*
Equipment Design
Lung / metabolism*
Models, Theoretical
Nebulizers and Vaporizers*
Reg. No./Substance:
0/Aerosol Propellants

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