| A comprehensive work up for an asthenozoospermic man with repeated intracytoplasmic sperm injection (ICSI) failure. | |
| | |
MedLine Citation:
|
PMID: 21762187 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Infertility affects about 15-20% couples attempting pregnancy and in about half cases the problem lies in the male. Among the sperm parameters, linear progressive motility is one of the most important predictors of fertility potential. Though genetic and chromosomal abnormalities are important aetiological factors in the pathogenesis of male infertility, the mechanism involved in impaired sperm motility is poorly understood. Here we report mitochondrial DNA (mtDNA) mutations with increased seminal reactive oxygen species (ROS) levels and higher DNA fragmentation level in the sperm resulting in decreased ATP production which plays an important role in sperm motility defect. Thus it is important to understand the aetiology of asthenozoospermia and to distinguish if infertile men harbour nuclear or mtDNA mutation as they are very important prognostic markers. This case study also highlights that routine semen parameters are very modest predictors of fertility outcome but ROS estimation and DNA integrity analysis by Comet assay have better diagnostic and prognostic capabilities. Thus this study is a detailed and comprehensive workup of an infertile asthenozoospermic male. |
| | |
Authors:
|
R Dada; R Z Mahfouz; R Kumar; S Venkatesh; M B Shamsi; A Agarwal; P Talwar; R K Sharma |
Related Documents
:
|
9742127 - Sld2, which interacts with dpb11 in saccharomyces cerevisiae, is required for chromosom... 2784387 - Coordinate replication of dispersed repetitive sequences in physarum polycephalum. 3016987 - Transposition and replication of maxi-mu derivatives of bacteriophage mu. 23251007 - γ-h2ax foci formation as a pharmacodynamic marker of dna damage produced by dna cross-... 9016597 - Evaluation of pyrimidine pna binding to ssdna targets from nonequilibrium melting exper... 11599817 - Detection of ehrlichia platys in dogs in australia. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-18 |
Journal Detail:
|
Title: Andrologia Volume: - ISSN: 1439-0271 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0423506 Medline TA: Andrologia Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 Blackwell Verlag GmbH. |
Affiliation:
|
Laboratory for Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India Center for Reproductive Medicine, Glickman Urological and Kidney Institute and Obstetrics and Gynecology and Women's Health Institute, Cleveland Clinic, Cleveland, OH, USA Army Research and Referral Hospital, New Delhi, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical features and natural history of hepatocellular adenomas: the impact of obesity.
Next Document: Effect of red maca (Lepidium meyenii) on prostate zinc levels in rats with testosterone-induced pros...