Document Detail

A comprehensive method of assessing routine CT scans in schizophrenia.
MedLine Citation:
PMID:  9395159     Owner:  NLM     Status:  MEDLINE    
Morphological brain abnormalities are common in schizophrenia, although the aetiological and clinical significance of these findings is largely unknown. Substantial between-subject variability suggests that large samples are needed to study the full implications of brain pathomorphology. Computerized tomography (CT) is frequently used routinely in schizophrenia, and large numbers of scans are available for study. This article describes the development and statistical properties of a rapid and simple method of assessing CT scans. The CT Rating Scale for Schizophrenia (CTRSS) is minimally affected by variability in scanning procedures, is reliable, and accurately estimates area and volumetric measures of brain spaces. By promoting the comprehensive assessment of large numbers of routinely obtained scans, the CTRSS would allow the investigation of variables that may systematically affect results (e.g. gender and age) and variables with low prevalence. The CTRSS provides a useful adjunct to technologically more sophisticated methods of assessment such as magnetic resonance imaging (MRI).
G N Smith; S W Flynn; L C Kopala; A S Bassett; J S Lapointe; P Falkai; W G Honer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta psychiatrica Scandinavica     Volume:  96     ISSN:  0001-690X     ISO Abbreviation:  Acta Psychiatr Scand     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-01-16     Completed Date:  1998-01-16     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0370364     Medline TA:  Acta Psychiatr Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  395-401     Citation Subset:  IM    
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Brain / radiography*
Brain Damage, Chronic / radiography*
Delirium, Dementia, Amnestic, Cognitive Disorders / radiography*
Middle Aged
Observer Variation
Psychiatric Status Rating Scales
Schizophrenia / radiography*
Schizophrenic Psychology*
Sensitivity and Specificity
Tomography, X-Ray Computed* / instrumentation,  statistics & numerical data
Grant Support
53216//Canadian Institutes of Health Research

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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