| A comprehensive computational model of facilitated diffusion in prokaryotes. | |
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MedLine Citation:
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PMID: 22492644 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MOTIVATION: Gene activity is mediated by site-specific transcription factors (TFs). Their binding to defined regions in the genome determines the rate at which their target genes are transcribed. RESULTS: We present a comprehensive computational model of the search process of TF for their genomic target site(s). The computational model considers: the DNA sequence, various TF species and the interaction of the individual molecules with the DNA or between themselves. We also demonstrate a systematic approach how to parametrize the system using available experimental data. |
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Authors:
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Nicolae Radu Zabet; Boris Adryan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-04-06 |
Journal Detail:
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Title: Bioinformatics (Oxford, England) Volume: 28 ISSN: 1367-4811 ISO Abbreviation: Bioinformatics Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-22 Completed Date: 2013-02-05 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 9808944 Medline TA: Bioinformatics Country: England |
Other Details:
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Languages: eng Pagination: 1517-24 Citation Subset: IM |
Affiliation:
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Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge, UK. n.r.zabet@gen.cam.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Computer Simulation* DNA / chemistry, metabolism* Escherichia coli / metabolism* Facilitated Diffusion Lac Repressors / chemistry, metabolism* Models, Chemical Thermodynamics Transcriptional Activation |
| Grant Support | |
ID/Acronym/Agency:
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G1002110//Medical Research Council; //Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Lac Repressors; 9007-49-2/DNA |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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