| A compound isolated from Schisandra chinensis induces apoptosis. | |
| | |
MedLine Citation:
|
PMID: 21903389 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Schizandra chinensis has been known to have five predominant tastes: salty, sweet, sour, astringent, and bitter. It has also been shown to have various effects on the cardiovascular system, gastrointestinal system, anti-inflammatory, central nervous system, endocrine system, and stress protect. However, its anti-cancer activity on colon carcinoma HCT-116 cells has not been yet been examined. Thus, in this study, we attempted to isolate a compound from Schisandra chinensis that induced apoptosis in HCT-116 cells. An active compound was found and identified to be Gomisin A. It displayed apoptotic activity through caspase-7 cleavage in colon carcinoma HCT-116 cells. In addition, we further assessed the effects of this compound using long-term survival clonogenic assay with HCT116 cells. |
| | |
Authors:
|
Doseok Hwang; Soon Young Shin; Younggiu Lee; Jiye Hyun; Yeonjoong Yong; Jun Cheol Park; Young Han Lee; Yoongho Lim |
Related Documents
:
|
16471259 - Immunopathological consequences of the loss of engulfment genes: the case of abca1. 22099179 - More than nervous: the emerging roles of plexins. 10889509 - Surface expression of phosphatidylserine on macrophages is required for phagocytosis of... 2657909 - Role of oxygen-dependent mechanisms in monoclonal-antibody-induced lysis of normal t ce... 1336129 - In vitro effect of diacetoxyscirpenol and deoxynivalenol on microbicidal activity of mu... 19353569 - The roles of monocytic heat shock protein 60 and toll-like receptors in the regional in... 14970329 - Regulation of expression of bcl-2 protein family member bim by t cell receptor triggering. 16699949 - The trail apoptotic pathway mediates proteasome inhibitor induced apoptosis in primary ... 2537689 - Leukotriene b4 is measurable in serum of smokers and nonsmokers. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-22 |
Journal Detail:
|
Title: Bioorganic & medicinal chemistry letters Volume: - ISSN: 1464-3405 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-9-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul 143-701, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cloning and characterization of a type III polyketide synthase from Aspergillus niger.
Next Document: Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibi...