Document Detail

The composition of saturated fatty acids in plasma phospholipids changes in a way to counteract changes in the mean melting point during pregnancy.
MedLine Citation:
PMID:  11214724     Owner:  NLM     Status:  MEDLINE    
It has been demonstrated that in pathological conditions with an increase in the calculated mean melting point (MMP) of phospholipid (PL) fatty acids (FA) there are changes in the composition of the saturated FA (SFA), which partially counteract this effect: shorter-chain SFA with lower melting points are increased, while longer-chain less fluid SFA are suppressed. The aim of this study was to determine whether there are differences in MMP during pregnancy and in the newborn and, if so, whether similar adaptive changes occur in the composition of the SFA. The FA composition of plasma PL was determined in healthy women (n = 16) twice during pregnancy (15-24 wk and 29-36 wk) and at delivery and in umbilical venous blood obtained at birth. The MMP of maternal PL was significantly higher at delivery compared to mid-gestation, due to a loss of highly unsaturated FA (HUFA) which were replaced by SFA. In addition, changes in the SFA occurred: 16:0 with lower melting point was higher while 18:0 with higher melting point was lower at delivery. MMP of PL FA in umbilical plasma was lower than in maternal plasma at delivery, which was due to higher HUFA content. In contrast to maternal plasma, 16:0 was lower while 18:0, 20:0, and 24:0 were higher in umbilical plasma resulting in a higher MMP of SFA, tending to raise the overall MMP. It can be concluded that, during pregnancy and in the newborn, the FA composition of SFA changes in a way to counteract changes in MMP induced by reduced and increased HUFA, respectively.
S R De Vriese; A C Houwelingen; G Hornstra; M Dhont; A B Christophe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  36     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-14     Completed Date:  2001-04-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-20     Citation Subset:  IM    
Department of Internal Medicine, Ghent University Hospital, Belgium.
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MeSH Terms
Arachidonic Acid / blood
Chemistry, Physical
Fatty Acids / blood*,  chemistry*
Fatty Acids, Omega-3 / blood
Fatty Acids, Omega-6
Fatty Acids, Unsaturated / blood
Fetal Blood / chemistry*
Gestational Age
Hot Temperature
Infant, Newborn
Linoleic Acid / blood
Palmitic Acid / blood
Phospholipids / blood*,  chemistry*
Physicochemical Phenomena
Stearic Acids / blood
Umbilical Veins
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 0/Phospholipids; 0/Stearic Acids; 2197-37-7/Linoleic Acid; 506-32-1/Arachidonic Acid; 57-10-3/Palmitic Acid; 57-11-4/stearic acid

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