| A composite index for determining the impact of oral ulcer activity in Behcet's disease and recurrent aphthous stomatitis. | |
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MedLine Citation:
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PMID: 19614861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although number, frequency and healing time of oral ulcers and pain are generally used for clinical practice and studies in Behcet's disease (BD) and recurrent aphthous stomatitis (RAS), no standardized activity index is currently present to monitor clinical manifestations associated with oral ulcers. The aim of this study was to develop a standardized composite index (CI) to assess oral ulcer activity in BD and RAS. METHODS: In this cross-sectional study, 121 patients with BD and 45 patients with RAS were included. Sixty-five percentage of BD and 68.9% of RAS patients were in active stage during the previous 3 months. The developed CI included the presence of oral ulcers, ulcer-related pain and functional status and was evaluated in patients with both active and inactive disease for content validity. RESULTS: Composite index score was observed to be higher in active patients with RAS (6.94 + or - 2.19) compared with active BD patients (6.01 + or - 2.04) (P = 0.04). The number of oral ulcers and healing time of oral ulcers were significantly higher in RAS compared with BD (P = 0.018, P = 0.001 respectively). CI score correlated with the number of oral ulcers in both BD and RAS (P = 0.000, P = 0.002 respectively). CI score was '0' for inactive patients without oral ulcer in BD and RAS. Conclusions: The presented CI as an oral ulcer activity index seems to be a reliable and suitable tool for evaluating the clinical impact and disease-specific problems in BD and RAS. |
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Authors:
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G Mumcu; H Sur; N Inanc; U Karacayli; H Cimilli; N Sisman; T Ergun; H Direskeneli |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-07-15 |
Journal Detail:
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Title: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology Volume: 38 ISSN: 1600-0714 ISO Abbreviation: J. Oral Pathol. Med. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-11 Completed Date: 2010-03-04 Revised Date: 2010-07-23 |
Medline Journal Info:
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Nlm Unique ID: 8911934 Medline TA: J Oral Pathol Med Country: Denmark |
Other Details:
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Languages: eng Pagination: 785-91 Citation Subset: D; IM |
Affiliation:
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Department of Health Management, Faculty of Health Sciences, Marmara University, Istanbul, Turkey. goncamumcu@marmara.edu.tr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Behcet Syndrome / classification*, drug therapy, physiopathology Case-Control Studies Colchicine / therapeutic use Cross-Sectional Studies Deglutition Disorders / classification Eating / physiology Female Humans Immunosuppressive Agents / therapeutic use Male Mastication / physiology Oral Ulcer / classification* Pain Measurement Pilot Projects Recurrence Reproducibility of Results Severity of Illness Index Speech Disorders / classification Stomatitis, Aphthous / classification*, physiopathology Taste Disorders / classification Time Factors Wound Healing / physiology |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 64-86-8/Colchicine |
| Comments/Corrections | |
Comment In:
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J Oral Pathol Med. 2010 Jul;39(6):510; author reply 511
[PMID:
20456613
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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