Document Detail

A composite index for determining the impact of oral ulcer activity in Behcet's disease and recurrent aphthous stomatitis.
MedLine Citation:
PMID:  19614861     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although number, frequency and healing time of oral ulcers and pain are generally used for clinical practice and studies in Behcet's disease (BD) and recurrent aphthous stomatitis (RAS), no standardized activity index is currently present to monitor clinical manifestations associated with oral ulcers. The aim of this study was to develop a standardized composite index (CI) to assess oral ulcer activity in BD and RAS.
METHODS: In this cross-sectional study, 121 patients with BD and 45 patients with RAS were included. Sixty-five percentage of BD and 68.9% of RAS patients were in active stage during the previous 3 months. The developed CI included the presence of oral ulcers, ulcer-related pain and functional status and was evaluated in patients with both active and inactive disease for content validity.
RESULTS: Composite index score was observed to be higher in active patients with RAS (6.94 + or - 2.19) compared with active BD patients (6.01 + or - 2.04) (P = 0.04). The number of oral ulcers and healing time of oral ulcers were significantly higher in RAS compared with BD (P = 0.018, P = 0.001 respectively). CI score correlated with the number of oral ulcers in both BD and RAS (P = 0.000, P = 0.002 respectively). CI score was '0' for inactive patients without oral ulcer in BD and RAS.
CONCLUSIONS: The presented CI as an oral ulcer activity index seems to be a reliable and suitable tool for evaluating the clinical impact and disease-specific problems in BD and RAS.
G Mumcu; H Sur; N Inanc; U Karacayli; H Cimilli; N Sisman; T Ergun; H Direskeneli
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-07-15
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  38     ISSN:  1600-0714     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-11     Completed Date:  2010-03-04     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  785-91     Citation Subset:  D; IM    
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MeSH Terms
Behcet Syndrome / classification*,  drug therapy,  physiopathology
Case-Control Studies
Colchicine / therapeutic use
Cross-Sectional Studies
Deglutition Disorders / classification
Eating / physiology
Immunosuppressive Agents / therapeutic use
Mastication / physiology
Oral Ulcer / classification*
Pain Measurement
Pilot Projects
Reproducibility of Results
Severity of Illness Index
Speech Disorders / classification
Stomatitis, Aphthous / classification*,  physiopathology
Taste Disorders / classification
Time Factors
Wound Healing / physiology
Reg. No./Substance:
0/Immunosuppressive Agents; SML2Y3J35T/Colchicine
Comment In:
J Oral Pathol Med. 2010 Jul;39(6):510; author reply 511   [PMID:  20456613 ]

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