Document Detail


A componential analysis of proverb interpretation in patients with frontal lobe epilepsy and temporal lobe epilepsy: relationships with disease-related factors.
MedLine Citation:
PMID:  17853125     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability to interpret nonliteral, metaphoric language was explored in patients with frontal lobe epilepsy (FLE) and temporal lobe epilepsy (TLE), and matched control participants, to determine (1) if patients with FLE were impaired in their interpretations relative to those with TLE and controls, and (2) if disease-related variables (e.g., age of seizure onset) predicted performances in either patient group. A total of 22 patients with FLE, 20 patients with TLE, and 23 controls were administered a test of proverb interpretation to assess their ability to grasp the abstract meaning of nonliteral language. Participants were presented with a series of proverbs and asked to provide an oral interpretation of each. Responses to each proverb were scored according to their accuracy and level of abstractness. Patients with FLE, but not TLE, were impaired relative to controls in their overall interpretation of proverbs. However, a subgroup analysis revealed that only patients with left FLE showed impaired interpretation accuracy relative to the other groups, whereas patients with both left FLE and left TLE showed impaired abstraction. Patients with FLE were also impaired when they were asked to select the best interpretation of the proverb from response alternatives. In patients with FLE, only a left-sided seizure focus was associated with poorer performance. In patients with TLE, both an early age of onset and a left-sided seizure focus predicted poorer performance. Overall, FLE patients exhibit greater impairment than TLE patients in interpreting proverbs. However, the nature and disease-specific correlates of impaired performances in proverb interpretation differ between the groups.
Authors:
Carrie R McDonald; Dean C Delis; Joel H Kramer; Evelyn S Tecoma; Vicente J Iragui
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-06-26
Journal Detail:
Title:  The Clinical neuropsychologist     Volume:  22     ISSN:  1385-4046     ISO Abbreviation:  Clin Neuropsychol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-01     Completed Date:  2008-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806548     Medline TA:  Clin Neuropsychol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  480-96     Citation Subset:  IM    
Affiliation:
Veterans Administration San Diego Healthcare System., USA camcdonald@ucsd.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Epilepsy, Frontal Lobe / physiopathology*
Epilepsy, Temporal Lobe / physiopathology*
Female
Humans
Male
Mental Processes / physiology*
Middle Aged
Neuropsychological Tests
Principal Component Analysis*
Problem Solving
Semantics*
Statistics, Nonparametric
Verbal Behavior
Grant Support
ID/Acronym/Agency:
T32-MH18399/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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