Document Detail

A component of retinal light adaptation mediated by the thyroid hormone cascade.
MedLine Citation:
PMID:  22039463     Owner:  NLM     Status:  MEDLINE    
Analysis with DNA-microrrays and real time PCR show that several genes involved in the thyroid hormone cascade, such as deiodinase 2 and 3 (Dio2 and Dio3) are differentially regulated by the circadian clock and by changes of the ambient light. The expression level of Dio2 in adult rats (2-3 months of age) kept continuously in darkness is modulated by the circadian clock and is up-regulated by 2 fold at midday. When the diurnal ambient light was on, the expression level of Dio2 increased by 4-8 fold and a consequent increase of the related protein was detected around the nuclei of retinal photoreceptors and of neurons in inner and outer nuclear layers. The expression level of Dio3 had a different temporal pattern and was down-regulated by diurnal light. Our results suggest that DIO2 and DIO3 have a role not only in the developing retina but also in the adult retina and are powerfully regulated by light. As the thyroid hormone is a ligand-inducible transcription factor controlling the expression of several target genes, the transcriptional activation of Dio2 could be a novel genomic component of light adaptation.
Diana E Bedolla; Vincent Torre
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-10-24
Journal Detail:
Title:  PloS one     Volume:  6     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-31     Completed Date:  2012-02-28     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e26334     Citation Subset:  IM    
Neurobiology Sector, International School for Advanced Studies (SISSA), Trieste, Italy.
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MeSH Terms
Adaptation, Physiological*
Base Sequence
Circadian Rhythm
DNA Primers
Iodide Peroxidase / genetics,  metabolism
Mice, Knockout
Oligonucleotide Array Sequence Analysis
Real-Time Polymerase Chain Reaction
Retina / enzymology,  physiology*
Thyroid Hormones / physiology*
Reg. No./Substance:
0/DNA Primers; 0/Thyroid Hormones; EC Peroxidase

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