Document Detail

A component analysis of the generation and release of isometric force in Parkinson's disease.
MedLine Citation:
PMID:  1640233     Owner:  NLM     Status:  MEDLINE    
Paradigms of isometric force control allow study of the generation and release of movement in the absence of complications due to disordered visuomotor coordination. The onset and release of isometric force in Parkinson's disease (PD) was studied, using computerised determinants of latency of response and rate of force generation and release. Components of isometric force control were related to measures of cognitive, affective and clinical motor disability. The effects of treatment were determined by longitudinal study of de novo patients. Patients with PD showed impairment in latency and rate of force change for movement release as well as onset. Rate of force change correlated with depression, clinical motor disability and memory quotient but latency showed no correlation with any of these measures. Treatment improved rate of force release, in concert with clinical motor disability, but not latency. These results suggest dissociations between latency and rate of force change that may be linked to different neurochemical deficits. Further, they demonstrate akinetic deficits in force release that argue against the "neural energy hypothesis" of akinesia.
N Jordan; H J Sagar; J A Cooper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  55     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-09-03     Completed Date:  1992-09-03     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  572-6     Citation Subset:  IM    
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK.
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MeSH Terms
Bromocriptine / administration & dosage
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Therapy, Combination
Isometric Contraction / drug effects,  physiology*
Levodopa / administration & dosage
Longitudinal Studies
Middle Aged
Motor Neurons / drug effects,  physiology
Muscles / innervation
Neurologic Examination* / drug effects
Parkinson Disease / diagnosis,  drug therapy,  physiopathology*
Reaction Time / drug effects
Trihexyphenidyl / administration & dosage
Reg. No./Substance:
0/Levodopa; 144-11-6/Trihexyphenidyl; 25614-03-3/Bromocriptine

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