Document Detail

A complication in anticoagulation using low-molecular weight heparin in a patient with a mechanical valve prosthesis. A case report.
MedLine Citation:
PMID:  11128796     Owner:  NLM     Status:  MEDLINE    
All mechanical heart valves are thrombogenic, and are associated with thromboembolic complications becomes ineffective. when anticoagulation Controversy exists with regard to the appropriate and safe anticoagulation regimen of gravid women with mechanical heart valve prostheses. While oral anticoagulants such as warfarin may be associated with fetal complications, the role of low-molecular weight heparin (LMWH) and heparinoids (and their respective appropriate dosage) have still to be determined. In developing countries such as Saudi Arabia, the prevalence of rheumatic fever is high, as is the percentage of female patients with mechanical heart valves and who are of child-bearing age. Thus, the issue of adequate anticoagulation on one hand, and avoidance of warfarin-induced embryopathy on the other hand, is crucial. To date, few reports are available of LMWH as sole anticoagulant in patients with mechanical heart valves. We report a case of massive valve thrombosis with subsequent pulmonary edema after warfarin anticoagulation was changed to LMWH during pregnancy, and administered at too low a dose.
N Berndt; I Khan; R Gallo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  9     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-20     Completed Date:  2001-02-08     Revised Date:  2006-05-04    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  844-6     Citation Subset:  IM    
Cardiac Services Department, Armed Forces Hospital, Southern Region Khamis Mushayt, Saudi Arabia.
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MeSH Terms
Anticoagulants / administration & dosage*
Dilatation and Curettage
Enoxaparin / administration & dosage*
Heart Valve Prosthesis / adverse effects*
Heart Valve Prosthesis Implantation
Mitral Valve* / surgery
Pregnancy Complications, Cardiovascular
Pregnancy Complications, Hematologic / prevention & control*,  surgery
Preoperative Care
Thrombosis / etiology*,  prevention & control,  surgery
Treatment Failure
Reg. No./Substance:
0/Anticoagulants; 0/Enoxaparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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