Document Detail

The complexity of management of pregnancy-associated malignant soft tissue and bone tumors.
MedLine Citation:
PMID:  17878735     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The incidence of musculoskeletal tumors during pregnancy is very low. The aim of this study was to summarize our experience in treating a large cohort of pregnant patients diagnosed with these rare tumors. METHODS: Women diagnosed with musculoskeletal tumors during pregnancy or immediately after delivery were identified retrospectively in our database between 1996 and 2006. Relevant maternal and neonatal data were collected. RESULTS: Twenty patients, 8 with bone sarcomas (BS) and 12 with soft tissue sarcomas (STS) were identified. Two women were treated by wide excision of mass during pregnancy. In all other cases oncological treatment was delayed until delivery or termination of pregnancy. Vaginal delivery was possible in 9 patients, cesarean section was performed in 7, spontaneous abortion occurred in 1, and 3 underwent termination of pregnancy. Three newborns were premature, but normal growth and development were observed. Different techniques of fertility preservation were used in our patients. Five patients with BS and 5 patients with STS received preoperative chemotherapy, with different grades of toxicity. The degree of tumor necrosis tended to correlate with dose-intensity of chemotherapy. Seven patients with BS received adjuvant chemotherapy. Two patients with STS received adjuvant chemotherapy, two - radiotherapy, and four - both modalities. Median disease-free survival was 15.1 months, median overall survival - 25.4 months. CONCLUSIONS: Musculoskeletal tumors diagnosed during pregnancy, or after delivery, do not appear to have a significant impact on the prognosis. A multidisciplinary team should tailor the oncological approach individually.
Rinat Bernstein Molho; Yehuda Kollender; Josephine Issakov; Jacob Bickels; Gideon Flusser; Fuad Azem; Adele Alon; Moshe J Inbar; Isaac Meller; Ofer Merimsky
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Publication Detail:
Type:  Journal Article     Date:  2007-09-18
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  65     ISSN:  1423-002X     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-05     Completed Date:  2008-04-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  89-95     Citation Subset:  IM    
Copyright Information:
(c) 2008 S. Karger AG, Basel.
Unit of Bone and Soft Tissue Oncology, Division of Oncology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
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MeSH Terms
Abortion, Induced
Bone Neoplasms / complications,  mortality,  therapy*
Cohort Studies
Combined Modality Therapy
Delivery, Obstetric*
Disease-Free Survival
Pregnancy Complications, Neoplastic / mortality,  therapy*
Pregnancy Outcome
Retrospective Studies
Sarcoma / complications,  mortality,  therapy*
Soft Tissue Neoplasms / complications,  mortality,  therapy*

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