| The complex world of WNT receptor signalling. | |
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MedLine Citation:
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PMID: 23151663 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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30 years after the identification of WNTs, their signal transduction has become increasingly complex, with the discovery of more than 15 receptors and co-receptors in seven protein families. The recent discovery of three receptor classes for the R-spondin family of WNT agonists further adds to this complexity. What emerges is an intricate network of receptors that form higher-order ligand-receptor complexes routing downstream signalling. These are regulated both extracellularly by agonists such as R-spondin and intracellularly by post-translational modifications such as phosphorylation, proteolytic processing and endocytosis. |
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Authors:
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Christof Niehrs |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-15 |
Journal Detail:
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Title: Nature reviews. Molecular cell biology Volume: - ISSN: 1471-0080 ISO Abbreviation: Nat. Rev. Mol. Cell Biol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100962782 Medline TA: Nat Rev Mol Cell Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Molecular Embryology, DKFZ-ZMBH Alliance, DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany, and Institute of Molecular Biology, 55128 Mainz, Germany. C.Niehrs@imb-mainz.de. |
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