| A complex role for complement in allergic asthma. | |
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MedLine Citation:
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PMID: 20402389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Allergic asthma is a chronic inflammatory disease of the upper airway. It is well appreciated that maladaptive Th2 immunity promotes the allergic phenotype, the underlying mechanisms of which remain elusive. The disease is associated with activation of complement, an ancient danger-sensing component of the innate immune system. Different models of experimental allergic asthma suggest that the small complement fragments of C3 and C5, the anaphylatoxins C3a and C5a, not only promote proallergic effector functions during the allergic effector phase but regulate the development of Th2 immunity during allergen sensitization. The available data support a concept in which C5a is dominant during allergen sensitization and protects against the development of maladaptive Th2 immunity. By contrast, C3a and C5a appear to act synergistically and drive allergic inflammation during the effector phase. In this article, we will review the recent findings in the field to judge the benefit of complement targeting in allergic asthma. |
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Authors:
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Xun Zhang; Jörg Köhl |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Expert review of clinical immunology Volume: 6 ISSN: 1744-666X ISO Abbreviation: Expert Rev Clin Immunol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-06-16 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 101271248 Medline TA: Expert Rev Clin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 269-77 Citation Subset: IM |
Affiliation:
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Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, OH 45229, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Asthma / immunology* Complement Activation Complement System Proteins / immunology* Disease Models, Animal Genetic Predisposition to Disease Genome-Wide Association Study Humans Immunity, Innate Immunization Signal Transduction Th2 Cells / immunology |
| Grant Support | |
ID/Acronym/Agency:
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AI057839/AI/NIAID NIH HHS; R01 AI057839-05/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-36-7/Complement System Proteins |
| Comments/Corrections | |
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